Ongoing Clinical Research Studies at Casa Colina

Translational and Clinical Neuroscience Laboratory

While numerous rehabilitative techniques are used to treat serious and potentially chronic cognitive and physical deficits, there remains a lack of available tools for effectively characterizing the temporal dynamics and individual variability of the brain’s response to therapeutic intervention. One area of focus in our research department is to identify useful biomarkers (molecular, imaging, and physiological) for recovery and treatment efficacy. In additional we want to begin to elucidate the mechanisms of activity, pathogenesis, and recovery for a stroke, traumatic brain injury, and spinal cord injury. Below is a list of current research studies in this area.

Active Projects

Analysis of brain dynamics during BI rehab

TBI biomarker study: neuroendocrine dysfunction and inflammatory / neural markers

Cognitive Neural prosthetics for SCI

Role of Genetic factors in Hemorrhagic Stroke

Presence of Micro-bleeds in neurological injury

Completed Projects

Longitudinal analysis of neural and inflammatory markers in individuals with TBI

Women with the Alzheimer’s risk marker ApoE4 lose Abeta specific CD4+ T cells 10-20 years before men

Hypothalamic Pituitary Dysfunction Following Traumatic Brain Injury

Hypothalamic-pituitary dysfunction following traumatic brain injury affects functional improvement during acute impatient rehabilitation.

The potential use of Hormone-based therapeutics for the treatment of Alzheimer’s disease

The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke

Clinical Informatics Laboratory

The majority of our research studies at Casa Colina are aimed to evaluate the efficacy of both current and novel treatments and programs at Casa Colina. We focus on the major diagnoses at Casa Colina to investigate new interventions, support evidence-based clinical practices, and develop predictive /assessment tools for the treatment of disabilities caused by a stroke, traumatic brain injury, spinal cord injury, and other neurologic conditions and movement disorders. Below is a list of current research studies in this area.

Active Projects

High Risk Navigation

Cognitive decline post joint replacement surgery

Predicting Rehabilitation and Discharge Success machine learning

A new scale to assess receptive language: validation in patients with aphasia

Fall risk assessment

Rehab outcomes and prediction analysis

Textured thin liquids on improved swallow outcomes

PD Deep Brain Stimulation rehab study

Predicting driving readiness

Estim for Dysphagia

Nerve and Tendon transfer for SCI patients

Completed Projects

Swim safety and social interaction for children with Autism

Patient Navigation for Spinal Cord Injury

Patient Navigation for Traumatic Brain Injury

Senior Evaluation Program outcomes

Effects of aquatic therapy on functional mobility and strength, Fall Risk and Self-reported disability in individuals with low back pain

The Effect of Amplification on Speech and Language Abilities In Children with Artesia

Predicting discharge destination with admission outcome scores in stroke patients

Pinch Strength and its Relationship to Penmanship and ADLs

Use of an Algorithm for Assessment and treatment of upper extremity post stroke

Predicting and Assessing Fall Risk in an Acute Inpatient Rehabilitation Facility

Multidimensional health risk appraisal among adults aging with acquired disabilities

Comparison of Fallers and Non-fallers at an Inpatient Rehabilitation Facility

The “Village”: A Seven-year Case study on Sustaining Healthy Choices Among Adults with Intellectual Disabilities

Dalcroze Eurhythmics in Transitional Care Brain Injury Patients

The Effect of Liquid Modifications on Dehydration and Quality of Life

Validation of the Casa Colina Falls Assessment Scale in predicting falls in Inpatient Rehabilitation Facilities

Technology Laboratory

Through collaborations with academic institutions and companies, we have recently embarked on a new area of research focused on physiological monitoring and technology. These studies investigate novel therapeutic interventions and the use of technology for monitoring patients and augment clinical care. Below is a list of current research studies in this area.

Active Projects

Home monitoring of gait in PD

Visual scene app for aphasia

Development of clinical tracking app

Completed Projects

Evaluation of Wearable “Smart Socks” Gait Monitoring System for Improving Rehabilitation through Remote Gait Monitoring

LEGO interventions for Social and Language Development

Sound and Visual cues to improve gait in individuals with PD

Effects of aquatic therapy on functional mobility and strength, Fall Risk and Self-reported disability in individuals with low back pain

For more information on current health outcomes research at Casa Colina, please contact:

Emily R. Rosario, Ph.D.
Director of Casa Colina Research Institute
909/596.7733, ext.3036