Translational Neuroscience
Translating basic science research into clinical application is a major
challenge within biomedical sciences. With a stated commitment to Clinical
Excellence, Education, and Research, Casa Colina provides a unique environment
for the transfer of knowledge between researchers and clinicians. At the
Casa Colina Research Institute, we conduct clinical studies that provide
a foundation for developing, or directly test, novel therapeutic strategies
for humans with nervous system disorders.
While numerous rehabilitative techniques are used to treat serious and
potentially chronic cognitive and physical deficits, there remains a lack
of available tools for effectively characterizing the temporal dynamics
and individual variability of the brain’s response to therapeutic
intervention. As such, the Casa Colina Research Institute seeks to identify
useful biomarkers (molecular, imaging, and physiological) for recovery
and treatment efficacy. Through this critical research, we are beginning
to elucidate the mechanisms of activity, pathogenesis, and recovery for
stroke, traumatic brain injury, and spinal cord injury.
Current Research Studies
In search of biomarkers for the recovery of patients with traumatic brain injury
This study aims to better understand recovery from traumatic brain injury
and identify biomarkers that will allow clinicians to predict outcomes
following injury and to optimize individualized treatment plans.
Relation between pain and depression: preliminary study on neural pathways
in patients with Fybromyalgia
Our researchers are exploring the association between brain structure and
pain/depression levels before and after an eight-week Fybromialgia program
offered at Casa Colina Hopsital and Centers for Healthcare.
Impact of increased sleep hygiene on patient outcome in acute rehabilitation setting
Scheduled rest and sleep seem to promote relaxation and reduction of stress
levels. However, even though interventions to promote inpatient rest and
sleep have been successfully trialed in critical care units, scant research
exists to indicate whether this practice has any effect on the recovery
from critical illness or injury in acute rehabilitation hospitals. Further
research is therefore required to investigate the impact of increasing
sleep hygiene on patient’s outcome in such setting.
Completed Research Studies
Evaluation of an augmentative and alternative communication intervention
in individuals with aphasia
This study tests the effectiveness of an iPad-based intervention for individuals
with aphasia. Autismate365 involves the use of visual scene displays,
which employ interactive images to support and enhance communication and
social interaction.